ASI is a professional non-profit organization of medical doctors and researchers in HIV/AIDS aiming to promote and disseminate clinically oriented medical teaching and coordinated medical management of HIV disease. ASI was established in the year 2000, after an intense lobbying by the former IAS presidents – Late Dr. Mark Wainberg and Dr. Stefano Vella with prominent Indian HIV experts. Today it is India’s largest association of HIV professionals with 650 members. It was started and slated to be affiliated to IAS and even ASI bylaws are in tandem with that IAS. However with change of IAS bylaws with respect to affiliations, it remained an enigma. ASI is registered under the Society’s Registration Act 1860 and the Bombay Public Trust Act 1950 in 2000 AD with its registered office at Mumbai. ASI plays a great advocacy role from time to time. Several of ASI suggestions and recommendations are part of “The Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome (Prevention and Control) Bill, 2014”; which was recently passed in both houses of the Indian Parliament. ASI collaborates with internationally recognized scientists in HIV/AIDS and focuses on national capacity building. ASI has been an important platform for a range of HIV clinicians from different medical disciplines and specialities as well as addresses a broad array of thematic issues like co-infections such as TB-HIV, HIV-Hepatitis or co-conditions like HIV and NCDs. ASI organizes national conferences (ASICON) since 2005 and from 2009 they are being held annually with the average attendance of 700 – 800 delegates, besides several continuing medical education (CME) sessions and training as well as thematic workshops in different parts of the country. ASI CMEs are popular and attendance peaked to 300. ASICONs and CMEs have continuously engaged not only HIV specialists, HIV organisations but also agencies such as the national TB programme, ICMR, private sector, pharmaceutical agencies, faith-based leaders, policy makers and planners and a galaxy of globally acclaimed HIV physicians and scientists over the years. ASI has been accredited by the Maharashtra Medical Council since 2013 for conducting CMEs, Workshops, Training Programs and Conferences with CME credit hours to delegates and faculty. All ASI CMEs and Workshops all over India are entitled with credit hours. ASI manages a discussion forum on its website www.asi-asicon.org and ASI plans to publish a newsletter/ journal in the near future.